At this moment I’m in the process of collecting all the references to be able to write my first publication. On this page the references I have so far. Keep in mind that some of the references used in posts aren’t perse papers I cite, but more often here than not examples of what I am trying to convey. The references are automatically updated from Zotero.
Reference list
- Anatomy education and innovation
- biodiversity, taxonomy and evolution
- protocols, ontologies
- techniques, 3d reconstructions, digital twins
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1.
Tan, K. Variation theory and the different ways of experiencing educational policy. Educ Res Policy Prac 8, 95–109 (2009).
1.
Falletta, P., Tagliatti, E. & Cortese, K. Seeing structure, losing sight: The case for morphological thinking in the age of integration. The Anatomical Record 309, 471–474 (2026).
1.
Castro, K. M. D. S. A., Amado, T. F., Bidau, C. J. & Martinez, P. A. Studying natural history far from the museum: the impact of 3D models on teaching, learning, and motivation. Journal of Biological Education 56, 598–608 (2022).
1.
Sharma, B., Nasir, N., Alhazmi, A., Bridget, B. & Ali, M. Visualizing Anatomy: Comparing the Pedagogical Impact of Chalkboard Teaching and 3D Models. Clinical Anatomy ca.70055 (2025) http://doi.org/10.1002/ca.70055.
1.
Bhattacharjee, S. et al. On the importance of integrating comparative anatomy and One Health perspectives in anatomy education. Journal of Anatomy 240, 429–446 (2022).
1.
Xiao, J. & Adnan, S. Flipped anatomy classroom integrating multimodal digital resources shows positive influence upon students’ experience and learning performance. Anatomical Sciences Ed 15, 1086–1102 (2022).
1.
Shin, M. et al. Anatomy education in US Medical Schools: before, during, and beyond COVID-19. BMC Med Educ 22, 103 (2022).
1.
Correia, J. C., Baatjes, K. & Smith, K. Anatomy and arts: student perspectives on clay modelling in anatomy education. Journal of Visual Communication in Medicine 48, 11–19 (2025).
1.
Tripodi, N. et al. The Impact of Three‐Dimensional Printed Anatomical Models on First‐Year Student Engagement in a Block Mode Delivery. Anatomical Sciences Ed 13, 769–777 (2020).
1.
Stroet, K., Opdenakker, M.-C. & Minnaert, A. What motivates early adolescents for school? A longitudinal analysis of associations between observed teaching and motivation. Contemporary Educational Psychology 42, 129–140 (2015).
1.
Stroet, K., Opdenakker, M.-C. & Minnaert, A. Effects of need supportive teaching on early adolescents’ motivation and engagement: A review of the literature. Educational Research Review 9, 65–87 (2013).
1.
Cortese, K. & Frascio, M. Reclaiming Anatomy as Method: From Morphological Reasoning to Clinical Relevance. Clinical Anatomy ca.70074 (2025) http://doi.org/10.1002/ca.70074.
1.
Xiao, J., Donkin, R. & Lathe, S. Digital Anatomy: A New Frontier in Health and Medical Science Education. Clinical Anatomy 39, 20–24 (2026).
1.
Chang Chan, A. Y.-C., Stapper, C. P., Bleys, R. L., Van Leeuwen, M. & Ten Cate, O. Are We Facing the End of Gross Anatomy Teaching as We Have Known It for Centuries? AMEP Volume 13, 1243–1250 (2022).
1.
Silverman, I., Choi, J. & Peters, M. The Hunter-Gatherer Theory of Sex Differences in Spatial Abilities: Data from 40 Countries. Arch Sex Behav 36, 261–268 (2007).
1.
Akle, V., Peña‐Silva, R. A., Valencia, D. M. & Rincón‐Perez, C. W. Validation of clay modeling as a learning tool for the periventricular structures of the human brain. Anatomical Sciences Ed 11, 137–145 (2018).
1.
Klement, B. J., Paulsen, D. F. & Wineski, L. E. Anatomy as the backbone of an integrated first year medical curriculum: Design and implementation. Anatomical Sciences Ed 4, 157–169 (2011).
1.
Nokovitch, L. et al. Visual–spatial abilities enhancement and spatial anatomy learning: A systematic review. Medical Education 59, 1322–1332 (2025).
1.
Nesse, R. M. et al. Making evolutionary biology a basic science for medicine. Proc. Natl. Acad. Sci. U.S.A. 107, 1800–1807 (2010).
1.
How to Use 3D Printing Innovations and Digital Storage to Democratize Anatomy Education. vol. 6 (Springer Nature Switzerland, Cham, 2024).
1.
Scalese, R. J., Obeso, V. T. & Issenberg, S. B. Simulation Technology for Skills Training and Competency Assessment in Medical Education. J GEN INTERN MED 23, 46–49 (2008).
1.
El Hammoumi, S., Zerhane, R. & Janati Idrissi, R. The impact of using interactive animation in biology education at Moroccan Universities and students’ attitudes towards animation and ICT in general. Social Sciences & Humanities Open 6, 100293 (2022).
1.
Teplá, M., Teplý, P. & Šmejkal, P. Influence of 3D models and animations on students in natural subjects. IJ STEM Ed 9, 65 (2022).
1.
Paim E Silva Cadete Tomás, K. D. et al. Applications of 3D printing in the teaching of human anatomy: An integrative review. Annals of 3D Printed Medicine 19, 100213 (2025).
1.
Abdel Meguid, E. M., Holland, J. C., Keenan, I. D. & Mishall, P. Exploring Visualisation for Embryology Education: A Twenty-First-Century Perspective. in Biomedical Visualisation (ed. Rea, P. M.) vol. 1356 173–193 (Springer International Publishing, Cham, 2022).
1.
McLaughlin, D., Keane, A., Quinn, J. & Tipping, N. The chick embryo model as an educational tool to explore the effect of alcohol on cardiovascular development. Advances in Physiology Education 49, 438–460 (2025).
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1.
One hundred and one new species of Trigonopterus weevils from New Guinea. ZooKeys 280, 1–150 (2013).
1.
Homberger, D. G. Models and tests in functional morphology: the significance of description and integration. Amer Zool 28, 217–229 (1988).
1.
Louca, S., Mazel, F., Doebeli, M. & Parfrey, L. W. A census-based estimate of Earth’s bacterial and archaeal diversity. PLoS Biol 17, e3000106 (2019).
1.
Locey, K. J. & Lennon, J. T. Scaling laws predict global microbial diversity. Proc. Natl. Acad. Sci. U.S.A. 113, 5970–5975 (2016).
1.
Mora, C., Tittensor, D. P., Adl, S., Simpson, A. G. B. & Worm, B. How Many Species Are There on Earth and in the Ocean? PLoS Biol 9, e1001127 (2011).
1.
Li, X. & Wiens, J. J. Estimating Global Biodiversity: The Role of Cryptic Insect Species. Systematic Biology 72, 391–403 (2023).
1.
Wiens, J. J. How many species are there on Earth? Progress and problems. PLoS Biol 21, e3002388 (2023).
1.
Mazzocchi, F. The limits of reductionism in biology: what alternatives? Elogos 18, 1–19 (2011).
1.
Diogo, R. & Molnar, J. Links between Evolution, Development, Human Anatomy, Pathology, and Medicine, with A Proposition of A Re‐defined Anatomical Position and Notes on Constraints and Morphological “Imperfections”. J Exp Zool Pt B 326, 215–224 (2016).
1.
Zhang, Z.-Q. Animal Biodiversity: An Outline of Higher-Level Classification and Survey of Taxonomic Richness. (Magnolia Press, Auckland, N.Z., 2011).
1.
Vinarski, M. V. Roots of the taxonomic impediment: Is the “integrativeness” a remedy? Integrative Zoology 15, 2–15 (2020).
1.
Löbl, I., Klausnitzer, B., Hartmann, M. & Krell, F.-T. The Silent Extinction of Species and Taxonomists—An Appeal to Science Policymakers and Legislators. Diversity 15, 1053 (2023).
1.
De Carvalho, M. R. et al. Taxonomic Impediment or Impediment to Taxonomy? A Commentary on Systematics and the Cybertaxonomic-Automation Paradigm. Evol Biol 34, 140–143 (2007).
1.
Ma’ayan, A. Complex systems biology. J. R. Soc. Interface. 14, 20170391 (2017).
1.
Nartallo-Kaluarachchi, R., Lambiotte, R. & Goriely, A. From reductionism to realism: Holistic mathematical modelling for complex biological systems. Preprint at https://doi.org/10.48550/arXiv.2503.20511 (2025).
1.
Narang, P. et al. The Evolution of 3D Anatomical Models: A Brief Historical Overview. World Neurosurgery 155, 135–143 (2021).
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1.
Yang, Z., Tang, C., Zhang, T., Zhang, Z. & Doan, D. T. Digital Twins in Construction: Architecture, Applications, Trends and Challenges. Buildings 14, 2616 (2024).
1.
Park, M. & Fishwick, P. A. Integrating Dynamic and Geometry Model Components through Ontology-Based Inference. SIMULATION 81, 795–813 (2005).
1.
Tarasov, S. Integration of Anatomy Ontologies and Evo-Devo Using Structured Markov Models Suggests a New Framework for Modeling Discrete Phenotypic Traits. Systematic Biology 68, 698–716 (2019).
1.
Boyer, D. M., Gunnell, G. F., Kaufman, S. & McGeary, T. M. MORPHOSOURCE: ARCHIVING AND SHARING 3-D DIGITAL SPECIMEN DATA. Paleontol. Soc. Pap. 22, 157–181 (2016).
1.
Mitsuhashi, N. et al. BodyParts3D: 3D structure database for anatomical concepts. Nucleic Acids Research 37, D782–D785 (2009).
1.
Ng, L. et al. The INCF Digital Atlasing Program: Report on Digital Atlasing Standards in the Rodent Brain. Nat Prec https://doi.org/10.1038/npre.2009.4000.1 (2009) doi:10.1038/npre.2009.4000.1.
1.
Bradford, Y. M. et al. Zebrafish information network, the knowledgebase for Danio rerio research. Genetics 220, iyac016 (2022).
1.
Gölz, L. et al. Development of a Zebrafish embryo-based test system for thyroid hormone system disruption: 3Rs in ecotoxicological research. Environmental Toxicology and Chemistry 44, 2485–2502 (2025).
1.
Gray, J. A. et al. The Diffusion Diaries: Diffusible Iodine-Based Contrast-Enhanced Computed Tomography for Vertebrate Natural History Specimens. Integr Org Biol 7, obaf014 (2025).
1.
Möller, M., Folz, C., Sintek, M., Seifert, S. & Wennerberg, P. Extending the Foundational Model of Anatomy with Automatically Acquired Spatial Relations. Nat Prec https://doi.org/10.1038/npre.2009.3471.1 (2009) doi:10.1038/npre.2009.3471.1.
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1.
Fahrni, S. & Sabatasso, S. 3D modelling in anatomy teaching: state of the art and pilot investigations for its application. Translational Research in Anatomy 41, 100444 (2025).
1.
Ezzell, Z., Fishwick, P. A., Lok, B., Pitkin, A. & Lampotang, S. An ontology-enabled user interface for simulation model construction and visualization. Journal of Simulation 5, 147–156 (2011).
1.
Kumar, P. et al. Integrating AI Segmentation, Simulated Digital Twins, and Extended Reality into Medical Education: A Narrative Technical Review and Proof-of-Concept Case Study. JPM 16, 202 (2026).
1.
Forjaz, A. et al. Whole organism 3D mapping reveals universal branching topology and biophysical optimization governs vascular and nervous system development. Preprint at https://doi.org/10.64898/2026.04.10.717729 (2026).
1.
Van De Kamp, T., Dos Santos Rolo, T., Vagovič, P., Baumbach, T. & Riedel, A. Three-Dimensional Reconstructions Come to Life – Interactive 3D PDF Animations in Functional Morphology. PLoS ONE 9, e102355 (2014).
1.
Salazar‐Fernández, A., Carretero, J. M., Rodríguez, L. & García‐González, R. Integrating whole‐bone and regional analyses to understand human scapular growth. The Anatomical Record ar.70156 (2026) http://doi.org/10.1002/ar.70156.
1.
Erolin, C. Interactive 3D Digital Models for Anatomy and Medical Education. in Biomedical Visualisation (ed. Rea, P. M.) vol. 1138 1–16 (Springer International Publishing, Cham, 2019).
1.
Andolfi, C., Plana, A., Kania, P., Banerjee, P. P. & Small, S. Usefulness of Three-Dimensional Modeling in Surgical Planning, Resident Training, and Patient Education. Journal of Laparoendoscopic & Advanced Surgical Techniques 27, 512–515 (2017).
1.
Bragantini, J. et al. Ultrack: pushing the limits of cell tracking across biological scales. Nat Methods 22, 2423–2436 (2025).
1.
Banerjee, I., Catalano, C. E., Patané, G. & Spagnuolo, M. Semantic annotation of 3D anatomical models to support diagnosis and follow-up analysis of musculoskeletal pathologies. Int J CARS 11, 707–720 (2016).
1.
Guo, Y., Veneman, W. J., Spaink, H. P. & Verbeek, F. J. Three-dimensional reconstruction and measurements of zebrafish larvae from high-throughput axial-view in vivo imaging. Biomed. Opt. Express 8, 2611 (2017).
1.
Verbeek, F. J. et al. Standard 3D digital atlas of zebrafish embryonic development for projection of experimental data. in (eds Beretta, G. B. & Schettini, R.) 242–252 (San Jose, CA, 1999). http://doi.org/10.1117/12.373465.
1.
Stoks, J., Chau Nguyen, U., Peeters, R., Volders, P. & Cluitmans, M. An Open-Source Algorithm for Standardized Bullseye Visualization of High-Resolution Cardiac Ventricular Data: UNISYS. in (2020). http://doi.org/10.22489/CinC.2020.160.
1.
Alaimo, L. et al. The Role of Three-Dimensional Modeling to Improve Comprehension of Liver Anatomy and Tumor Characteristics for Medical Students and Surgical Residents. Journal of Surgical Education 81, 597–606 (2024).
1.
El-Wajeh, Y. A. M., Hatton, P. V. & Lee, N. J. Unreal Engine 5 and immersive surgical training: translating advances in gaming technology into extended-reality surgical simulation training programmes. British Journal of Surgery 109, 470–471 (2022).
1.
Somepalli, M. R., Charan, M. D. S., Shruthi, S. & Palaniswamy, S. Implementation of Single Camera Markerless Facial Motion Capture using Blendshapes. in 2021 IEEE International Conference on Computation System and Information Technology for Sustainable Solutions (CSITSS) 1–6 (IEEE, Bangalore, India, 2021). http://doi.org/10.1109/CSITSS54238.2021.9683460.
1.
Gerbaud, S. et al. Topological 3D reconstruction of multiple anatomical structures from volumetric medical data. Computers & Graphics 121, 103947 (2024).
1.
Wu, D. et al. A diffusion MRI-based spatiotemporal continuum of the embryonic mouse brain for probing gene–neuroanatomy connections. Proc. Natl. Acad. Sci. U.S.A. 119, e2111869119 (2022).
1.
Lobachev, O., Berthold, M., Pfeffer, H., Guthe, M. & Steiniger, B. S. Inspection of Histological 3D Reconstructions in Virtual Reality. Front. Virtual Real. 2, 628449 (2021).
1.
Erolin, C. Preference for detail in 3D anatomical models amongst professionals and laypersons. Journal of Visual Communication in Medicine 48, 87–98 (2025).
1.
Armeni, P. et al. Digital Twins in Healthcare: Is It the Beginning of a New Era of Evidence-Based Medicine? A Critical Review. JPM 12, 1255 (2022).
1.
Verbeek, F. J., Boon, P. J., Sloetjes, H., Van Der Velde, R. & Vos, N. Visualization of complex data sets over Internet: 2D and 3D visualization of the 3D digital atlas of zebrafish development. in (eds Beretta, G. B. & Schettini, R.) 20–29 (San Jose, CA, 2001). http://doi.org/10.1117/12.452680.
1.
Gahlawat, M. & Tanwar, S. Digital Twin and Blockchain for Sustainable Healthcare 5.0: Real-Life Applications and Case Studies. (Chapman and Hall/CRC, Boca Raton, 2025). http://doi.org/10.1201/9781003532286.
1.
The Digital Twin. (Springer International Publishing, Cham, 2023). http://doi.org/10.1007/978-3-031-21343-4.
1.
Ezzell, Z. A UNIFIED HUMAN INTERACTION-BASED THEORY AND FRAMEWORK FOR SIMULATION MODELING AND VISUALIZATION DESIGN.
1.
Smallridge, M. W. et al. Three-dimensional exploration of the chicken embryo, a comparative study of light sheet and histological visualisation. PLoS ONE 20, e0320483 (2025).
1.
Potter, R., Rönnlund, R. & Wallensten, J. An evaluation of Substance Painter and Mari as visualisation methods using the Piraeus Lion and its runic inscriptions as a case study. Herit Sci 11, (2023).
1.
Van Riel, S. Applying 3D stratigraphic reconstruction to a large rescue archaeology site. A case study of the medieval and early modern submarine topography in Oslo, Norway. Digital Applications in Archaeology and Cultural Heritage 34, e00357 (2024).
1.
Edelmers, E., Kazoka, D., Bolocko, K. & Pilmane, M. Different Techniques of Creating Bone Digital 3D Models from Natural Specimens. ASI 5, 85 (2022).
1.
Kang, R. et al. Embodiment design of soft continuum robots. Advances in Mechanical Engineering 8, (2016).
1.
Nobles, G. R. & Roosevelt, C. H. Filling the Void in Archaeological Excavations: 2D Point Clouds to 3D Volumes. Open Archaeology 7, 589–614 (2021).
1.
Sueters, J. et al. Micro-computed tomography to visualize preserved vascular architecture in decellularized human vaginal tissue: explorative study. Sci Rep 15, 30533 (2025).
1.
Ji, Y., Hong, Y., Bhandari, D. R. & Yee, D. W. Hydrogel‐Based Vat Photopolymerization of Ceramics and Metals with Low Shrinkages via Repeated Infusion Precipitation. Advanced Materials e04951 (2025) http://doi.org/10.1002/adma.202504951.
1.
Frank, D. D. et al. A reference brain for the clonal raider ant. Preprint at https://doi.org/10.1101/2025.10.13.679875 (2025).
1.
Anderson, C. et al. A 3D molecular atlas of the chick embryonic heart. Developmental Biology 456, 40–46 (2019).
1.
Bastian, M., Heymann, S. & Jacomy, M. Gephi: An Open Source Software for Exploring and Manipulating Networks. ICWSM 3, 361–362 (2009).
1.
Faludi, B. et al. Direct Visual and Haptic Volume Rendering of Medical Data Sets for an Immersive Exploration in Virtual Reality. in Medical Image Computing and Computer Assisted Intervention – MICCAI 2019 (eds Shen, D. et al.) vol. 11768 29–37 (Springer International Publishing, Cham, 2019).
1.
Bakker, B. S. de. 3D Atlas of Human Embryology: New Insights in Human Development. (Academic Medical Center, University of Amsterdam, Amsterdam, 2018).
1.
Plum, F. & Labonte, D. scAnt —an open-source platform for the creation of 3D models of arthropods (and other small objects). PeerJ 9, e11155 (2021).
1.
Irschick, D. J. et al. 3D visualization processes for recreating and studying organismal form. iScience 25, 104867 (2022).
1.
Zhihao Zhu et al. A randomized cohort study on the use of 3D printed models to enhance surgical training in suturing techniques. Sci Rep 15, (2025).
1.
Kamminga, P., De Bruin, P. W., Geleijns, J. & Brazeau, M. D. X-ray computed tomography library of shark anatomy and lower jaw surface models. Sci Data 4, 170047 (2017).